A new mouse study has found consuming Omega-3 Fatty Acids may stop a lupus episode and possibly the trigger of other autoimmune conditions. The research specifically looked at lung and kidney lesions caused by lupus, an autoimmune condition. 96% of these lung lesions were halted with supplementation of DHA.
Female mice who were already genetically predisposed to lupus took part in this preclinical study. The mice were fed diets that contained 0%, .4%, 1.2% or 2.4% DHA. After 2 weeks of this protocol the mice were then exposed weekly to 1 mg of crystalline silica (cSIO2), also known as quartz which is a know trigger of the autoimmune response in the lungs and kidneys. This lasted for 4 weeks. The mice were given their diet containing the DHA for an additional 12 weeks.
The mice were assessed for markers of autoimmunity and inflammation in the kidneys, lungs and blood. Certain antibodies (CD45R+) found in the lung were reduced in accordance with the amount of DHA consumed. A 96% reduction was seen in the group receiving the highest amount of DHA (2.4%). Immune cell (CD3+) numbers in the lung were also reduced with an 83% reduction seen in the mice receiving the 2.4% DHA in their diet.
Researchers believe the DHA may be changing the method in which macrophages, healthy cells, responded to the silica in the lungs and might actually be changing the response of the immune system.
Further studies are warranted.
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