A new study has found a combination of the amino acid L-Arginine, Folic Acid, Vitamin B6 and Vitamin B12 may improve vascular function in addition to supporting a reduction in blood pressure.
81 people participated in this placebo-controlled clinical trial. Study participants ranged in age from 40 to 65 years of age and were randomly assigned to receive a placebo or a combination of L-arginine and B vitamins (3 mg of B6, .4 mg of Folic acid, 2 mcg of B12 or 2400 mg of L-Arginine). The study lasted for 6 months, 3 months with the assigned supplement combination or the placebo and 3 months with no supplementation.
Results showed a .37 increase in the reactive hyperemia index (RHI), a measure of endothelial function which shows improvements in vascular function, in the group taking the actual supplements with no significant changes seen in the group taking the placebo. Additionally systolic blood pressure decreased significantly (6 mmHg) over the study period in the group supplementing with the actual supplement combination with no changes seen in the placebo group.
Most recently even modest changes in blood pressure (5 mmHg) were considered as being clinically significant and were associated with a 9% reduction in coronary heart disease risk and a 14% reduction in stroke risk.
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