A new systematic review was undertaken to determine how supplementation with Melatonin affected blood lipids. Researchers reviewed eight Random Controlled Trials. Participants in these studies ranged in age from 16 years old to 74 years old and with the exception of one of the studies included both men and women (one of the studies included only male participants).
A significant relationship between supplementation with Melatonin and reductions in total cholesterol levels as well as a reduction in triglycerides was seen in this meta-analysis. The mechanism for lipid reduction associated with Melatonin was attributed to Melatonin’s ability to suppress visceral fat which ultimately prevented cholesterol synthesis and absorption while improving LDL receptor activity and inhibiting metabotropic receptors which aid in the transport of fatty acids. A noticeable reduction was also seen in VLDL (very low-density lipoprotein) cholesterol in the participants who supplemented with Melatonin. Researchers believe this effect occurs when intestinal cholesterol absorption has been suppressed. Reductions in triglycerides were also seen in participants who supplemented with 8mg doses of Melatonin for a period of 8 weeks.
Researchers concluded that Melatonin supplementation had a significant effect on lowering total cholesterol and triglycerides and a minor effect on improving HDL cholesterol and LDL cholesterol as well as providing protection from LDL oxidation which may contribute to Melatonin’s supporting role in preventing atherosclerosis. LDL oxidation is a major activation step in atherosclerosis development. Additionally, researchers found considerable evidence that point to Melatonin’s ability to act as a strong antioxidant.
Further studies are needed to determine all the benefits Melatonin may provide for supporting a healthier lipid profile.
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