Researchers have found a link in the progression of Liver Fibrosis in Non-Alcoholic Fatty Liver Disease (NAFLD) and two important B Vitamins.
Over 80 patients with Non-Alcoholic Steatohepatisis (NASH), a progressive form of Non Fatty Liver Disease, participated in this study. The average age of the study participants was 41 years old. The study included 32 women and 51 men. Liver biopsies were analyzed using the SAF (steatosis, activity, and fibrosis) scoring system to determine the degree of NASH in each participant. Additionally blood levels of B12 and Folate were taken and correlations were made between the stages of the disease progression.
Researchers determined an inverse relationship existed between the grades of fibrosis (formation of scar tissue) in the liver and blood levels of Folate and Vitamin B12. Lower serum Vitamin B12 levels were also associated with a higher severity of NASH. Non-Alcoholic Steatohepatitis is known to start as a simple steatosis (the accumulation of fat cells in the liver) and then progress to NASH as scar tissue (fibrosis) occurs.
Further studies are needed in order to determine the pathological role of low Vitamin B12 and Low Folate in the development of NASH.
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