A 13% reduction in the risk of developing Type-2 Diabetes was seen in individuals who took in more than 500 IU of Vitamin D daily according to data published in the European Journal of Clinical Nutrition. Additionally people who had the highest blood levels of Vitamin D (measured as greater than 25 ng/ml) had a 43% lower risk of developing Type-2 Diabetes when compared with individuals with the lowest Vitamin D blood levels (measured as less than 14 ng/ml).
A meta-analysis of 11 randomized controlled studies and 8 observational cohort studies were used to support these findings.
Vitamin D refers to 2 biologically inactive precursors-D2 (ergocalciferol) and D3 (cholecalciferol). D2 and D3 precursors are processed in the liver and kidneys into 25-hydroxyvitamin D (25(OH)D) which represents the non-active “storage” form and 1,25-dihydroxyvitamin D (1,25(OH)2D) which is the biologically active form and is tightly controlled by the body.
Deficiencies in Vitamin D have been linked to the impairment of insulin secretions in both humans and animals and have been linked to insulin resistance in otherwise healthy glucose-tolerant subjects.
The World Health Organization says over 220 million people worldwide are affected by Diabetes with the consequences of high blood sugar killing over 3 million people annually. The World Health Organization estimates that the death rate from Diabetes will double before 2030.
Vitamin D deficiency is also believed to increase and worsen Osteopenia, Osteoporosis, Bone Fractures, Muscle Weakness, Autoimmune Diseases, Cardiovascular Disease, Infectious Diseases and some types of Cancer.
Further studies including high quality observational and RCTs are needed.
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