A new clinical study examining Resveratrol supplementation and its ability to support Healthy Aging in Women was just released showing the benefits this phyto-nutrient has on cognition, cerebrovascular function and cardiometabolic markers in postmenopausal women.
125 postmenopausal women, participated in this 24 month randomized, placebo-controlled crossover trial. Participants between the ages of 45 – 85 years of age supplemented 75mg of trans-resveratrol or a placebo twice daily for a period of 12 months. They then crossed over to the alternative treatment for the remaining 12 months of the study. A wide range of cognitive tests which measured many cognitive areas were performed during the 12 month intervals. Differences between the 2 treatment periods measured cognition as a primary outcome, cerebrovascular function in the middle cerebral artery and cardio-metabolic markers as secondary outcomes.
The participants who supplemented with the Resveratrol saw a 33% improvement in overall cognitive performance when compared to the group supplementing with the placebo. Women over the age of 65 showed a relative improvement in verbal memory with Resveratrol supplementation compared to women less than 65 years of age. A 12% improvement in cerebrovascular responsiveness (CVR) to hypercapnia (excessive carbon dioxide in the bloodstream) was reported with Resveratrol supplementation. Neurovascular coupling was improved by 7% with Resveratrol supplementation.
Exit surveys done showed more than half the study participants reported improvements in perceived memory, mood and other aspects of living while supplementing with Resveratrol.
Researchers concluded estrogen deprivation can increase age-related arterial stiffening as well as impair tissue perfusion by reducing endothelium-dependent vasodilatation which increases cerbrovascular diseases as well as dementia risks. These 2 factors are becoming the leading causes of death in older women. Women over the age of 55, have a greater risk of developing cardiovascular diseases than younger women or even their male counterparts. A rapid mid-life reduction in circulating estrogen after menopause is partly responsible for these differences. Estrogen is necessary for bone health, metabolic regulation and memory retention in pre-menopausal women. It is believed that estrogen loss could accelerate age-related cognitive impairment and increase cardiovascular disease risks. In 2016 dementia mortality rates in women were almost twice that of men.
Further studies are underway.
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