A new meta-analysis and review appearing in Human Reproduction found higher Vitamin D levels were associated with better birth rates in women receiving fertility treatment.
11 studies with over 2,700 women undergoing fertility treatment, frozen embryo transfer, in vitro fertilization (IVF), and/or intracytoplasmic sperm injection (ICSI) were reviewed. Participants Vitamin D status was measured by means of blood tests. 75 nanomoles per liter (nmol/L) was considered to be a sufficient Vitamin D status while 50 nmol/L was considered to be deficient. Vitamin D status between those 2 defined limits was considered as insufficient.
Results showed a high amount of Vitamin D deficiency among the study participants with only 26% of women participating in these studies having sufficient serum Vitamin D levels. Additionally 35% of participants had deficient levels of Vitamin D and 45% had insufficient Vitamin D levels. Researchers also found that women with adequate Vitamin D levels had a 33% higher likelihood of having a live birth when compared with participants whose Vitamin D status was either insufficient or deficient. Additionally other conception related outcomes were improved in participants with sufficient Vitamin D levels. Women achieving a positive pregnancy test two weeks after an embryo transfer were 34% higher in women with sufficient Vitamin D status when compared with participants with either insufficient or deficient Vitamin D levels. In studies measuring the presence of a fetal heart beat at 5 weeks after an embryo transfer (“Clinical Pregnancy”), a 46% improvement in outcome was seen in participants considered to have sufficient Vitamin D levels.
Researchers stressed that although no causal connection could be attributed to Vitamin D and pregnancy outcomes, treating Vitamin D deficiency and insufficiency could be essential to women undergoing fertility treatment. Additionally researchers believe a randomized controlled trial is needed to investigate the benefits of Vitamin D deficiency and fertility treatment outcomes.
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