According to a new meta-analysis and systematic review published in the journal Scientific Vitamin E supplementation may affect PCOS (polycystic ovary syndrome) patient’s hormonal and metabolic parameters in a positive way.
PCOS is a common disease of the endocrine gland and occurs in women of reproductive age. PCOS is associated with certain metabolic disorders like Type 2 Diabetes Mellitus (T2DM), high blood pressure (Hypertension), high cholesterol (dyslipidemia), cardiovascular disease (CVD), and atherosclerosis.
A total of 12 studies which involved randomized controlled trials were reviewed for this study. Participants were all above 18 years of age, diagnosed with PCOS and either receiving a Vitamin E supplement or a placebo.
4 of the 12 studies were evaluated for pre and post vitamin supplementation and evaluated participant’s testosterone levels. A significant decrease in this hormone was seen between the control groups and the intervention groups.
7 of the 12 studies looked at Vitamin E and its impact on BMI (body mass index). 2 of these 7 studies showed a small decrease in BMI levels after Vitamin E and CoQ10 supplementation. Weight changes were insignificant.
3 of the 12 studies showed promising results on HOMA scores. Additionally changes in insulin levels and insulin resistance parameters were also seen, however Vitamin E alone did not show a similar impact.
Based on the overall review results Vitamin E was shown to decrease both testosterone and LH levels and also increase progesterone and FSH levels. No significant changes in estradiol or DHEAS levels were seen with Vitamin E supplementation.
Researchers concluded that Vitamin E supplementation positively affects hormonal and metabolic parameters in patients diagnosed with PCOS.
Further studies are needed.
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