A new study found that supplementing with a multi-strain Probiotic and Omega-3 support anti-inflammatory activity which reduces low grade inflammation and lowers the risk of age-related chronic disease in the elderly.
91 individuals participated in this random study. Participants were between the ages of 65 and 80. Study subjects had a normal BMI range (defined as 18.5-27 kg/m) and a blood hs-CRP (high sensitivity C-reactive protein) of 1.5-6 mg/l. The study lasted 8 weeks. Participants supplemented with 640 mg of Omega-3 (1100 mg of Fish Oil) and a multi strain Probiotic or a placebo of maltodextrin (for the Probiotic) and sunflower oil (for the Omega-3). Participants were instructed to maintain their typical diet throughout the study period.
At the end of the study period lower values of hs-CRP in the supplement group were seen. Additionally significantly higher levels of IL-10, an anti-inflammatory cytokine, were seen in the supplement group when compared to the placebo group. No differences in gastrointestinal permeability between the two groups was seen however increases in valeric short chain fatty acid (SCFA), which is involved in favorable immune regulation, was seen in the supplement group.
The study findings support the original hypothesis researchers had suggesting the combination of a multi strain Probiotic and Omega-3 can reduce inflammaging (chronic low grade inflammation) in older adults. Inflammaging is becoming endemic in the elderly population and increases the risks of cardiovascular disease, infections and impaired physical and physiological functioning.
Probiotics and Omega 3 individually have proven in past studies to have a modulating effect on inflammation and immune function. This study was a first in that it combined the effects of these two supplements and their impact on age-related chronic low grade inflammation.
Larger studies are called for.
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