According to a Dutch research group, supplementation with Resveratrol seems to lower the values that measure average blood sugar level.
41 overweight men and women participated in this parallel-group, double-blind clinical study. For the first 2 weeks, participants were asked to stop eating any foods rich in Resveratrol like Peanuts, Red Wine and Grapes. 20 participants were randomized to receive a 150 mg Resveratrol supplement and 21 participants received a placebo. The study lasted 6 months. Blood Pressure and Body Weight were measured as well as a plasma analysis of Resveratrol levels.
No differences were seen between the Resveratrol group and the placebo group in insulin sensitivity. However, researchers found a significant difference in post intervention HbA1c (glycated hemoglobin) levels between the two groups. The Resveratrol group showed lower HbA1c levels (35.8 mmol/mol) compared to the placebo group (37.6 mmol/mol). HbA1c is a marker of long-term glycemic control and reflects the average plasma glucose values of the prior three months.
Resveratrol is a natural polyphenol and has been identified as a promising activator of SIRT1 (Protein Sirtuin 1). SIRT1 plays an important role in mediating the effects seen in metabolic stress situations like high fat diets and increased obesity. Hence, compounds known to activate SIRT1 either directly or indirectly may offer protection against metabolic dysfunction and promote a healthier aging process. Other studies of individuals who were overweight and individuals with Type 2 Diabetes showed participants supplementing with a low dose Resveratrol supplement experienced improvements in muscle mitochondrial oxidative capacity after just a few weeks.
Further studies are needed.
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